3D printed poly(hydroxybutyrate-co-hydroxyvalerate)—45S5 bioactive glass composite resorbable scaffolds suitable for bone regeneration

3D printing for tissue engineering requires biomaterials with mechanical and biological properties suitable both regeneration the process. A filament made of poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) combined 45S5 Bioglass (BG) was used to print scaffolds by fused deposition modeling (FDM). Chemical treatment BG particles chlorotrimethylsilane (CTMS) improved ductility extruded filaments allowed excellent printability. Controlling parameter infill density (I%), from 20 90%, were obtained interconnected pores channel sizes in 100–800 µm range exhibiting tensile modulus 0.25 1.36 GPa. PHBV + coated CTMS treated particles, as a model rough biologically active coating, showed no cytotoxic effects, cells preferred containing terms cell spreading. Mechanical similar those extracellular matrix (ECM) trabecular bone.